ABSTRACT
Background: Coronavirus 2019 (COVID-19) is a novel viral respiratory disease caused by severe acute respiratory syndrome coronavirus 2, it affects all systems in human body even reproductive system. Aim of the study: The aim of this study was to evaluate hormonal dysfunction in male after Covid-19 recovery by estimation of luteinizing hormone, testosterone and inhibin-B. Material and Methods: A cross-sectional study was carried out in Salah Al-Din Governorate from of December 2021 to the end of April 2022, included 60 patient who have +ve PCR of previously hospitalized and with oxygen ventilation and have moderate to severe covid-19 after 6 months of recovery, the second group 30 patient that apparently be healthy as control group and evaluation of total testosterone, luteinizing hormone, Inhibin-B by enzyme linked immunosorbent assay technique. Results: The study showed no significant difference between Covid-19 patients (6 months after recovery) and health control group, the mean age of patients was 33.11 year. The study showed that the lowest mean of testosterone was recorded among Covid-19 patients (2.78 ng/ml) as compared with healthy control individuals (7.43 ng/ml) at P. value <0.001. The study showed that the mean of inhibin-B was highly reduced in recover Covid-19 patients (41.13 pg/ml) comparing with control group (76.84 pg/ml) at P. value <0.001. The study showed that the mean of luteinizing hormone was elevated significantly in recover Covid-19 patients (5.80 IU/L) comparing with control group (2.39 IU/L) at P. value <0.05. The study showed significant negative correlation between CRP and each of testosterone and inhibin-B among recovered Covid-19 patients and significant positive correlation with luteinizing hormone There was a significant negative correlation between luteinizing hormone and testosterone. Conclusions: There was a significant relation between male dysfunction and Covid-19 infection and low levels of inhibin-B and testosterone were recorded among recover Covid-19 patients comparing with healthy individuals. © 2022, ResearchTrentz Academy Publishing Education Services. All rights reserved.
ABSTRACT
With the worldwide threat of SARS-CoV-2 as well as the growing number of infectious agents, little is recognized about how such a virus impacts the reproductive-system of males. This new coronavirus illness (COVID-19) outbreak puts men at a greater risk than females. So far, research on the andrological effects of coronavirus has been limited. The purpose of this study was to see how COVID-19 affected sperm characteristics in infertile males. Such study includes 30 males in total. In the prospective cohort study, different demographic as well as semen parameters have been assessed. The demographic factors including age, BMI, diabetes, and hypertension have somehow little or no effect on the patients after the COVID-19 diagnosis. Furthermore, the semen characteristics include sperm count and concentration, total motility, semen volume, and progressive motility. The COVID-19 infection has a significant impact on all these parameters. We present significant experimental proof that the COVID-19 outbreak can harm and target male fertility. The long-term outcomes of coronavirus on the reproductive systems of males have yet to be determined. Infection with SARS-CoV-2 can impair men’s reproductive function. Standard treatment plans must be made timely to protect infected patients’ fertility. Fertility evaluations and competent fertility assistance should be offered concurrently for recovered individuals with fertility needs. © 2022, ResearchTrentz Academy Publishing Education Services. All rights reserved.